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Contraindicated (1)pentobarbital will lower the extent or impact of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or influence of atazanavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.pentobarbital decreases amounts of amphoteric